Zhang Lab中文

PUBLICATIONS

Ideas, experiments,
discoveries.

Ten representative publications, alongside a recent methods preprint. Includes collaborative work completed before the lab’s establishment.

11 publications

In press
Figure 1: XDP genetic origin and the strategy for engineering humanized TAF1 in mouse embryonic stem cells, with validation data.
Preprint figure
Zhang et al., 2025CC BY-NC-ND 4.0
Cell · In pressDisease biology

Genome writing to dissect consequences of SVA retrotransposon disease X-Linked Dystonia Parkinsonism

Zhang, W.†, Zhao, Y., Prakash, P., et al.

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Zhang, W.†, Zhao, Y., Prakash, P., Appleby, H.L., Barriball, K., Capponi, S., Jiang, Q., Wudzinska, A.M., Vaine, C.A., Ellis, G., Rahman, N., Markovic, S., Mishkit, O., Limberg, K.C., Maurano, M.T., Wadghiri, Y.Z., Kim, S.Y., Timmers, H.T.M., Bragg, D.C., Liddelow, S.A., Brosh, R.†, Boeke, J.D.†.

Cell, in press, as listed in the faculty profile. Link and Figure 1 refer to the 2025 preprint.

† Corresponding authors

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2024
Figure 1: Pig-to-human kidney xenotransplantation study design and single-cell transcriptomic landscape.
Figure 1 · Original source
Pan et al., 2024
MedDisease biology

Cellular dynamics in pig-to-human kidney xenotransplantation

Pan, W.*, Zhang, W.*, Zheng, B.*, et al.

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Pan, W.*, Zhang, W.*, Zheng, B.*, Camellato, B., Stern, J., Lin, Z., Khodadadi-Jamayran, A., Kim, J., Sommer, P., Khalil, K., Weldon, E., Bai, J., Zhu, Y., Meyn, P., Heguy, A., Mangiola, M., Griesemer, A., Keating, B.J., Montgomery, R.A., Xia, B., Boeke, J.D.

5(8), 1016–1029.e4

* Equal contribution

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2023
Graphical abstract accompanying 10.1016/j.molcel.2023.10.015
Graphical abstract
Zhang et al., 2023
Molecular CellGenome function

Manipulating the 3D organization of the largest synthetic yeast chromosome

Zhang, W., Lazar-Stefanita, L., Yamashita, H., et al.

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Zhang, W., Lazar-Stefanita, L., Yamashita, H., Shen, M.J., Mitchell, L.A., Kurasawa, H., Haase, M.A.B., Sun, X., Jiang, Q., Lauer, S.L., McCulloch, L.H., Zhao, Y., Ichikawa, D., Easo, N., Lin, S.J., Fanfani, V., Camellato, B.R., Zhu, Y., Cai, J., Xu, Z., Build-A-Genome, Zeller, K., Bader, J.S., Stracquadanio, G., Deutsch, S., Aizawa, Y., Dai, J., Boeke, J.D.

83, 4424–4437.e7

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2023
Figure 1: Design and assembly of synthetic yeast chromosome IX, with assembly strategies and validation.
Figure 1 · Original source
McCulloch et al., 2023CC BY-NC-ND 4.0
Cell GenomicsGenome writing

Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains

McCulloch, L.H., Sambasivam, V., Hughes, A.L., et al.

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McCulloch, L.H., Sambasivam, V., Hughes, A.L., Annaluru, N., Ramalingam, S., Fanfani, V., Lobzaev, E., Mitchell, L.A., Richardson, S.M., Cai, J., The Build A Genome Class, Sims, J.J., Bishai, W.R., Cooper, E., Muller, H., Zeller, K., Stracquadanio, G., Steinmetz, L.M., Bader, J.S., Zhang, W.†, Boeke, J.D.†, Chandrasegaran, S.†.

3(11), 100419

† Corresponding authors

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2017
Provided figure accompanying 10.1126/science.aaf3981
Provided figure
Zhang et al., 2017
ScienceGenome writing

Engineering the ribosomal DNA in a megabase synthetic chromosome

Zhang, W.*, Zhao, G.*, Luo, Z.*, et al.

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Zhang, W.*, Zhao, G.*, Luo, Z.*, Lin, Y., Wang, L., Guo, Y., Wang, A., Jiang, S., Jiang, Q., Wang, Y., Hou, S., Huang, J., Li, T., Qin, Y., Dong, J., Qin, Q., Zhang, J., Zou, X., He, X., Zhao, L., Xiao, Y., Shen, Y., Kuang, Z., Mitchell, L., Yang, K., Richardson, S., Chen, G., Yuan, Y., Yang, H., Lin, J., Wu, Q., Bader, J., Cai, Y., Boeke, J., Dai, J.

355(6329), eaaf3981

* Equal contribution

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Publication images link to the original articles. Preprint figures and graphical abstracts are identified. Faculty publication list