OUR SCIENCE
From sequence
to understanding.
We use genome writing as an experimental approach to explore how DNA shapes biological function.
How can we write mammalian genomes at scale?
What do complex genomic regions do?
How do genomic changes cause disease?
GENOME WRITING & ENGINEERING
Build the tools.
Expand the questions.
What becomes experimentally accessible when we can rewrite larger stretches of a genome?
We develop technologies for mammalian genome writing and editing, opening up ways to construct and compare designed genomic sequences.
Write designed sequences to test how the genome works.
COMPLEX GENOMIC REGIONS
Understand the
genome in context.
How does a regulatory element’s surrounding sequence influence its function?
We investigate large regulatory elements and complex genomic regions, where studying an isolated sequence may miss the contribution of its genomic context.
DISEASE MODELS & MECHANISMS
From association
toward causality.
Which genomic alterations drive disease, and how?
We construct cellular and animal models to examine the biological consequences of genomic changes and investigate mechanisms that may inform future interventions.