Zhang Lab中文
Weimin Zhang, Principal InvestigatorWEIMIN ZHANG · 张维民

PRINCIPAL INVESTIGATOR

Weimin Zhang 张维民

Assistant Professor
School of Life Sciences, Tsinghua University

Investigator
Tsinghua–Peking Center for Life Sciences

Weimin’s research spans synthetic genomes and mammalian genome engineering. His lab develops approaches to study genome function and the mechanisms of human disease.

Faculty profileORCIDEmail

Portrait: Tsinghua University faculty profile.

EDUCATION & EXPERIENCE

A path through
synthetic genomics.

  1. 2026 — PRESENT

    Tsinghua University

    Assistant Professor · School of Life Sciences
    Investigator · Tsinghua–Peking Center for Life Sciences

  2. 2023 — 2026

    NYU School of Medicine

    Research Assistant Professor

  3. 2018 — 2023

    NYU School of Medicine

    Postdoctoral Researcher

  4. 2012 — 2018

    Tsinghua University

    PhD

  5. 2008 — 2012

    China Agricultural University

    Bachelor’s degree

Selected publications

In press
Figure 1: XDP genetic origin and the strategy for engineering humanized TAF1 in mouse embryonic stem cells, with validation data.
Preprint figure
Zhang et al., 2025CC BY-NC-ND 4.0
Cell · In pressDisease biology

Genome writing to dissect consequences of SVA retrotransposon disease X-Linked Dystonia Parkinsonism

Zhang, W.†, Zhao, Y., Prakash, P., et al.

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Zhang, W.†, Zhao, Y., Prakash, P., Appleby, H.L., Barriball, K., Capponi, S., Jiang, Q., Wudzinska, A.M., Vaine, C.A., Ellis, G., Rahman, N., Markovic, S., Mishkit, O., Limberg, K.C., Maurano, M.T., Wadghiri, Y.Z., Kim, S.Y., Timmers, H.T.M., Bragg, D.C., Liddelow, S.A., Brosh, R.†, Boeke, J.D.†.

Cell, in press, as listed in the faculty profile. Link and Figure 1 refer to the 2025 preprint.

† Corresponding authors

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2024
Figure 1: Pig-to-human kidney xenotransplantation study design and single-cell transcriptomic landscape.
Figure 1 · Original source
Pan et al., 2024
MedDisease biology

Cellular dynamics in pig-to-human kidney xenotransplantation

Pan, W.*, Zhang, W.*, Zheng, B.*, et al.

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Pan, W.*, Zhang, W.*, Zheng, B.*, Camellato, B., Stern, J., Lin, Z., Khodadadi-Jamayran, A., Kim, J., Sommer, P., Khalil, K., Weldon, E., Bai, J., Zhu, Y., Meyn, P., Heguy, A., Mangiola, M., Griesemer, A., Keating, B.J., Montgomery, R.A., Xia, B., Boeke, J.D.

5(8), 1016–1029.e4

* Equal contribution

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2023
Graphical abstract accompanying 10.1016/j.molcel.2023.10.015
Graphical abstract
Zhang et al., 2023
Molecular CellGenome function

Manipulating the 3D organization of the largest synthetic yeast chromosome

Zhang, W., Lazar-Stefanita, L., Yamashita, H., et al.

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Zhang, W., Lazar-Stefanita, L., Yamashita, H., Shen, M.J., Mitchell, L.A., Kurasawa, H., Haase, M.A.B., Sun, X., Jiang, Q., Lauer, S.L., McCulloch, L.H., Zhao, Y., Ichikawa, D., Easo, N., Lin, S.J., Fanfani, V., Camellato, B.R., Zhu, Y., Cai, J., Xu, Z., Build-A-Genome, Zeller, K., Bader, J.S., Stracquadanio, G., Deutsch, S., Aizawa, Y., Dai, J., Boeke, J.D.

83, 4424–4437.e7

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2023
Figure 1: Design and assembly of synthetic yeast chromosome IX, with assembly strategies and validation.
Figure 1 · Original source
McCulloch et al., 2023CC BY-NC-ND 4.0
Cell GenomicsGenome writing

Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains

McCulloch, L.H., Sambasivam, V., Hughes, A.L., et al.

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McCulloch, L.H., Sambasivam, V., Hughes, A.L., Annaluru, N., Ramalingam, S., Fanfani, V., Lobzaev, E., Mitchell, L.A., Richardson, S.M., Cai, J., The Build A Genome Class, Sims, J.J., Bishai, W.R., Cooper, E., Muller, H., Zeller, K., Stracquadanio, G., Steinmetz, L.M., Bader, J.S., Zhang, W.†, Boeke, J.D.†, Chandrasegaran, S.†.

3(11), 100419

† Corresponding authors

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2017
Provided figure accompanying 10.1126/science.aaf3981
Provided figure
Zhang et al., 2017
ScienceGenome writing

Engineering the ribosomal DNA in a megabase synthetic chromosome

Zhang, W.*, Zhao, G.*, Luo, Z.*, et al.

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Zhang, W.*, Zhao, G.*, Luo, Z.*, Lin, Y., Wang, L., Guo, Y., Wang, A., Jiang, S., Jiang, Q., Wang, Y., Hou, S., Huang, J., Li, T., Qin, Y., Dong, J., Qin, Q., Zhang, J., Zou, X., He, X., Zhao, L., Xiao, Y., Shen, Y., Kuang, Z., Mitchell, L., Yang, K., Richardson, S., Chen, G., Yuan, Y., Yang, H., Lin, J., Wu, Q., Bader, J., Cai, Y., Boeke, J., Dai, J.

355(6329), eaaf3981

* Equal contribution

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